How is PRoMPT BOLUS different from other clinical trials?

Most clinical trials outline very strict eligibility criteria for enrollment and provide an extensive protocol of therapy for subjects in the study.  However, PRoMPT BOLUS is a pragmatic clinical trial, which means that the study conditions mimic “real life” as much as possible with simple inclusion criteria, few exclusion criteria, and very few elements of care that are protocolized.  Our goal is to compare NS and LR as they may be used in ordinary clinical care.