What is sepsis?
Sepsis is a potentially life threatening response to infection that

  • Affects over 70,000 children in the United States every year
  • Can happen to someone of any age
  • Can cause damage to many of the body’s organs
  • Can prevent a person from being able to function normally or independently
  • Can limit awareness and cause coma
  • Can cause death

How is sepsis treated?
Sepsis is treated with emergency therapies that include antibiotics and fluids, usually given through an IV.  The most common place for sepsis to be treated when it occurs in the community is in an emergency department (ED).

PRoMPT BOLUS is a clinical trial to compare two IV fluid treatments for pediatric sepsis.  One fluid is normal saline (NS) and the other is lactated ringers (LR).  Both fluids are commonly used and both are helpful to treat pediatric sepsis but we do not yet know which fluid is the safest and most effective.

PRoMPT BOLUS began as pilot version at CHOP that helped us to improve the design of the study in the best possible way. The study will enter into a Pennsylvania Vanguard Phase during which CHOP and UPMC Children’s Hospital of Pittsburgh will enroll patients. PRoMPT BOLUS will ultimately be a large clinical trial that will enroll over 8,000 children with sepsis across the United States.