Study Population

PRoMPT BOLUS will enroll children over 6 months and less than 18 years of age with possible sepsis during a CHOP or Children’s Hospital Pittsburgh emergency department visit.  Children will be considered to have possible sepsis if their doctor thinks they may have sepsis that will require treatment with both IV antibiotics and IV fluids and their doctor is worried about possible shock.  The study will include children who are previously healthy, as well as children with chronic medical problems.